Pico Laser in Singapore: Treatment, Suitability and Recovery

Pico laser in Singapore at The Skin Longevity Clinic

Pico laser is a picosecond-pulse laser used for selected pigmentation, tattoo removal, uneven tone and, with a fractional handpiece, certain acne scars1. In Singapore it is one of the most widely advertised aesthetic treatments. Advertising volume is a poor guide to suitability, as the outcome is determined by which pigment is being treated rather than by how powerful the laser is.

Dr Rachel Ho’s approach is to identify the pigment type first, treat the visible excess, then reduce the triggers responsible for recurrence. That sequence matters, as pigment removed without trigger control returns within months, and the same laser applied to the wrong diagnosis can darken the skin rather than clear it.

Pico laser may help freckles, sun spots and age spots, post-acne dark marks, selected melasma, Hori’s naevus, tattoos, dullness and atrophic acne scars1,2. It does not reliably treat redness or broken capillaries, active acne, deep wrinkles, skin laxity, enlarged pores, raised scars, or pigmentation that recurs because its triggers remain untreated. Enlarged pores are assessed on the large pores treatment page.

Medically reviewed by Dr Rachel Ho, MBBS, MRCS, MMed (ENT), 3 October 2026.

What is pico laser?

Pico laser delivers energy in pulses measured in picoseconds, that is, trillionths of a second. Because the pulse is shorter than the time heat needs to spread into surrounding tissue, the dominant effect is photoacoustic rather than thermal. Pigment particles are fractured mechanically instead of being heated1. The fragments are then cleared by the skin’s immune and lymphatic systems over the weeks that follow.

Older Q-switched lasers operate in nanoseconds, a thousand times longer, so the same energy is delivered over an interval long enough for heat to spread. They remain effective for many pigment problems, and the choice between the two platforms depends on diagnosis, skin tone, downtime tolerance and cost rather than on which is newer3. Our comparison of pico laser versus Q-switched and yellow laser sets the differences out in detail.

A 2021 systematic review of 77 studies graded the evidence as level I for tattoo removal, level I to IV for benign pigmented lesions, level II for melasma and for rejuvenation, and level II to III for scar revision1. Level I is the strongest grade in that scheme, so the evidence supporting tattoo removal is considerably firmer than the evidence supporting melasma treatment.

Pico Laser Singapore: what it treats and what it does not

Best suited for Not ideal for
Freckles Facial redness
Sun spots Broken capillaries
Post acne dark marks Active acne
Selected pigmentation Skin laxity
Tattoo pigment Deep wrinkles
Mild uneven tone Raised scars
Selected acne scar texture with fractional Pico Keloids
Unstable or untreated melasma

What can pico laser treat? Pigmentation, melasma and acne marks

Pico laser for pigmentation in Singapore: picosecond pulses fragment pigment into finer particles with lower collateral heat, used for sun spots, freckles, selected melasma and post-inflammatory hyperpigmentation
Pico laser for pigmentation: how picosecond pulses fragment pigment for natural clearance.

Freckles, sun spots and age spots

Freckles, sun spots and age spots lie within the epidermis, which makes them the most predictable pico laser targets, as superficial pigment is reached at lower energy and cleared in fewer sessions. Across clinical trials, picosecond lasers cleared solar lentigines in 67.9 to 93 per cent of cases, compared with 36 to 77 per cent for Q-switched lasers4. In a split-face randomised trial in Asian patients, 85.7 per cent of picosecond-treated sites showed more than 50 per cent improvement at six months, against 57.2 per cent for the Q-switched side, with less treatment discomfort and no difference in side effects3. Read which freckles, sun spots and age spots respond best to laser. A 532 nm picosecond laser cleared more than 75% of 93% of sun spots in one session in Asian patients10, and a randomised trial found 532 nm picosecond and nanosecond lasers equally effective, with higher satisfaction on the picosecond side11. The pigmentation treatment guide compares all pigment types.

Pico laser for sun spots in Singapore: precise targeting of solar lentigines with lower collateral heat and gradual lightening over the following weeks
Pico laser for sun spots: precise pigment targeting and gradual lightening.
Dr Rachel Ho explains why freckles and age spots (solar lentigines) are different types of dark spots.

Melasma

Melasma is chronic and relapse-prone, driven by ultraviolet and visible light, heat, hormonal influence, inflammation and impaired barrier function. A 2023 meta-analysis found that low-fluence 1064 nm picosecond laser significantly reduced melasma severity scores without significant side effects, whereas 755 nm picosecond laser was not superior to topical agents and caused post-inflammatory hyperpigmentation5. Pico laser is therefore used for melasma at this clinic as one part of a long-term plan with sun protection, trigger control and topical maintenance, not as a cure. Singapore’s year-round ultraviolet exposure and ambient heat make that maintenance layer the harder half of the plan, as pigment suppressed by laser alone recurs once the triggers resume. See why melasma comes back and where pico laser fits. In a split-face randomised trial, 1064 nm picosecond and nanosecond lasers improved melasma equally, with less pain on the picosecond side12. Our pigmentation treatment guide covers the full melasma plan.

Pico laser for melasma in Singapore: evidence in Asian skin, relapse risk and the maintenance needed with sunscreen and topical care
Pico laser for melasma: used in selected cases as part of a broader plan, with maintenance.

Post-acne dark marks (post-inflammatory hyperpigmentation)

Post-inflammatory hyperpigmentation (PIH) responds once the acne driving it is controlled. Inflammation stimulates melanocytes to deposit additional pigment, so treating marks while breakouts continue is counterproductive, as each new lesion generates a fresh deposit faster than the laser clears the old one. Many post-acne marks also fade without any laser over three to twelve months once the inflammation settles, so acne control is addressed first and laser is reserved for pigment that persists beyond that window. Our guide to acne marks versus acne scars explains how the two are told apart and treated.

Hori’s naevus and other dermal pigment

Hori’s naevus, acquired bilateral naevus of Ota-like macules, is frequently mistaken for melasma or freckles and is a common reason pigmentation persists despite repeated laser treatment. The pigment sits in the dermis rather than the epidermis, beyond the reach of topical agents and of any wavelength that stops at the surface, which is why treatment aimed at epidermal pigment produces no visible change. A 2026 systematic review pooling 40 studies found 47.8 per cent of patients reached at least 75 per cent clearance with Q-switched or picosecond lasers, with response depending on the number of sessions6. Our article on why pigmentation returns or darkens after laser covers why the diagnosis matters. Picosecond treatment of Hori’s naevus in Asian patients was reported in JAMA Dermatology in 201813.

Dullness and uneven tone

Low-fluence toning passes across the whole face can improve tone and clarity with little downtime. Each pass fragments a small proportion of the dispersed epidermal pigment and provokes a mild dermal remodelling response, so the change accumulates across a series rather than appearing after one session. The evidence for rejuvenation is graded level II1. Results also depend on skincare, sun protection and sleep, as continued ultraviolet exposure and poor recovery generate fresh pigment while the laser is clearing the old. Our dull skin page covers the wider options.

Acne scars and skin texture

With a fractional handpiece (diffractive lens array or micro-lens array), pico laser creates microscopic columns of laser-induced optical breakdown that trigger collagen remodelling without removing the skin surface. Because the epidermis is left intact, the healing response proceeds without the surface injury that drives post-inflammatory hyperpigmentation in darker skin. In a randomised split-face trial for atrophic acne scars, fractional picosecond 1064 nm laser matched fractional CO2 laser for texture and scar volume, with no post-inflammatory hyperpigmentation on the picosecond side against 24 per cent on the CO2 side7. Deep, tethered or mixed scars still need combination treatment, as a tethered scar is held down by fibrous bands that collagen stimulation alone does not release. Our acne scar treatment page describes the combinations used.

Tattoo removal

Tattoo removal carries the strongest evidence grade for picosecond lasers1. In a systematic review of human trials, 69 to 100 per cent of tattoos showed more than 70 per cent clearance after one to ten treatments8. A 2022 systematic review of 36 studies found picosecond and Q-switched lasers both safe and effective for black ink, with picosecond superior for blue, green and yellow pigments9. Those colours absorb poorly at the wavelengths older lasers deliver and are the pigments most often left behind by earlier treatment. Clearance still depends on ink colour, depth, density, body site and the efficiency of the individual immune response, so complete removal cannot be promised before assessment. See our tattoo removal page.

What pico laser does not treat

Facial redness, flushing and broken capillaries are vascular rather than pigmentary and require a laser that targets haemoglobin, such as a yellow or pulsed dye laser. Active acne requires control of oil, congestion, bacteria and inflammation before any laser is directed at the marks it leaves. Sagging, hollowing and deep folds are structural problems addressed by collagen stimulation, injectables, energy-based tightening or surgery. Deep etched lines usually require ablative resurfacing or a combination approach rather than fractional pico alone. Pores are normal structures whose appearance varies with sebum production, elasticity and congestion, and no laser removes them. Raised scars and keloids behave differently from atrophic scars and need scar-specific care, as stimulating collagen in a scar already producing too much of it can worsen the appearance.

Diagnosis first: Not all types of hyperpigmentation are the same

Pigment concern Freckles Sun spots Post acne dark marks/ post inflammatory hyperpigmentation Melasma Hori’s naevus or dermal pigment
What it may look like Small brown spots, often sun related Discrete brown patches or spots Brown marks after breakouts Diffuse brown grey patches Deeper blue grey or brown grey pigment
Can Pico laser help Often yes Often yes Sometimes Sometimes, selected cases only Sometimes, selected cases only
What else may be needed Sun protection and maintenance skincare Assessment to confirm diagnosis Acne control and barrier repair Topicals, light protection, pigment stabilisation May need sequential treatments
Key limitation Can recur with UV exposure Not all brown spots are benign pigment New acne can create new marks Relapse is common Often slower response

Is pico laser safe for Asian skin?

Asian skin, typically Fitzpatrick types III to V, carries more baseline melanin and more reactive melanocytes, so heat, irritation or an aggressive setting is more likely to provoke post-inflammatory hyperpigmentation. Conservative settings and an accurate diagnosis are therefore the controlling variables, rather than the choice of laser itself. A meta-analysis of picosecond laser in Asian patients found 56 per cent were rated excellent and a further 29 per cent good for pigment clearance by a dermatologist at least three months after treatment, with similar results across 532, 755 and 1064 nm wavelengths2.

The most common error is treating every brown patch with the same settings. Freckles, sun spots, melasma, Hori’s naevus, post-acne marks and irritation pigment are difficult to separate on inspection alone yet respond differently to identical energy, and melasma in particular can darken under settings that clear a sun spot. Durable improvement depends further on control of inflammation, restoration of the skin barrier, reduction of ultraviolet and visible light exposure, and maintenance that lowers recurrence. The Concerns page on pigmentation treatment for Asian skin explains how each pigment type is identified.

What to expect after Pico laser

Treatment style Gentle toning style treatment Spot pigment treatment Fractional Pico for texture Tattoo pigment treatment
Possible visible effect Mild redness or warmth Temporary darkening or light crusting Redness, mild swelling, roughness Redness, swelling, frosting or crusting
Typical recovery pattern Often settles quickly Pigment may lift or fade gradually May take several days depending on settings Multiple sessions usually needed
What to avoid Heat, harsh exfoliation, strong actives Picking, scrubbing, sun exposure Exercise heat, exfoliation, aggressive skincare Picking and sun exposure
When to contact the clinic If irritation worsens or persists If blistering, pain or swelling occurs If prolonged swelling or unexpected reaction occurs If signs of infection or marked reaction occur

How is pico laser treatment performed?

Consultation. Dr Rachel Ho examines the pigment pattern, skin tone, recent sun exposure, skincare actives, medical history and any sign of irritation or unstable melasma. Photographs are taken under standardised distance and lighting, so that change is assessed against a fixed baseline rather than from memory. Treatment may be postponed if the skin is sunburnt, tanned, inflamed or infected.

Preparation. Make-up is removed and the skin cleansed. Numbing cream is optional for spot treatment or fractional passes. Toning passes are usually performed without it, as the sensation is mild.

Treatment. The handpiece delivers pulses to the target areas, and patients describe a light snapping or prickling sensation. A full-face toning session takes about 15 to 20 minutes. Spot treatment of individual lesions is shorter, whereas fractional treatment for scars takes longer and is more intense.

Immediately after. Redness and mild swelling are usual. Treated sun spots darken over the first few days before the fragmented pigment is shed as fine crusts, which is the expected sequence rather than a sign of worsening. Fractional treatment produces a fine grid of pinpoint marks. Sunscreen is applied before leaving.

Review. Discrete pigment is reviewed at four to six weeks, by which time the fragmented pigment has cleared. Melasma and post-inflammatory hyperpigmentation are reviewed at each session in a planned series, so that settings can be reduced at the first sign of rebound. Scars are reviewed at three months, when new collagen is measurable.

The pico laser device used at the clinic

The Skin Longevity Clinic uses the PicoPlus picosecond laser, a dual-wavelength 1064 nm and 532 nm neodymium YAG platform with a fractional handpiece. The two wavelengths reach different depths, the 532 nm beam being absorbed by superficial pigment and the 1064 nm beam penetrating to dermal pigment and tattoo ink, so epidermal pigment, dermal pigment, tattoo ink and acne scars are treated with one system.

The fractional handpiece and the lower energy toning mode suit different concerns. Our guide to pico toning vs fractional pico laser explains how each is selected.

How many pico laser sessions are needed?

Discrete sun spots or freckles often clear in one to three sessions. Post-acne marks and uneven tone require a series of four to six low-fluence sessions at two to four-week intervals, followed by maintenance. Melasma requires a longer plan, usually monthly low-fluence sessions with topical therapy, reviewed at each visit for response and rebound5. Atrophic acne scars require three to five fractional sessions four to six weeks apart7. Tattoos require multiple sessions six to eight weeks apart, and the number depends on ink colour, depth and density8,9. The intervals are set by clearance rather than by convenience, as the immune system needs several weeks to remove fragmented pigment before a further pass is useful.

Pico laser versus Q switched laser versus other options

Treatment type Pico laser Q switched laser Topical pigment treatment
Common role Selected pigment, tattoo pigment, texture with fractional handpiece Pigment toning and selected pigment disorders Melasma, post inflammatory pigmentation, maintenance
Strength Short pulse duration and reduced surrounding heat compared with older laser types Established technology with long clinical use Helps control pigment pathways and recurrence
Limitation Still carries pigment rebound risk if used wrongly May not be ideal for every pigment type or every patient Takes time and consistency
Best used when Diagnosis fits and skin is stable Doctor chooses it based on diagnosis Pigmentation is chronic or relapse prone

Our guide to pico laser results and how many sessions you may need sets out the published treatment schedules by concern and when improvement is assessed.

Pico laser downtime and side effects

Pico laser downtime ranges from none, for toning passes, to five to seven days of darkening and fine crusting after spot treatment of sun spots, and two to five days of redness and grid marks after fractional treatment for scars. Reported side effects include discomfort, redness, swelling, pinpoint bleeding, crusting, blistering, post-inflammatory hyperpigmentation, lightening of pigment and, rarely, scarring1,3. The risk rises with treatment of the wrong pigment, excessive settings, recent tanning, a compromised barrier or poor aftercare. Recent tanning matters because melanin dispersed through sun-exposed skin competes with the target pigment for the laser’s energy, which both lowers clearance and raises the chance of a burn.

Our pico laser recovery guide sets out the day-by-day course, the aftercare required and the symptoms that warrant review, namely increasing pain, blistering, darkening spreading beyond the treated spot, or any sign of infection.

Pico laser downtime in Singapore: redness for 1 to 2 days, pigment darkening on days 2 to 7, possible dryness or pinpoint crusting, and aftercare tips
Pico laser downtime: what to expect after treatment, with aftercare tips.

Benefits and disadvantages of pico laser

The benefits and disadvantages of pico laser depend on what is being treated. It works best when the diagnosis is a pigment it can target, and least well when the problem is redness, laxity or melasma treated without topical care and sun protection.

Benefits of pico laserDisadvantages of pico laser
Strong evidence for discrete pigment: sun spots and freckles often clear in one to three sessions4,10Melasma and post-acne marks need a course of sessions, and melasma needs maintenance5
Shorter pulses fragment pigment with less heat; in an Asian split-face trial it was rated less uncomfortable than Q-switched laser3Treated spots darken and crust for about five to seven days before they lighten
One device covers several concerns: toning for uneven tone, spot treatment and a fractional mode for acne scars and texture1,7Small risk of post-inflammatory hyperpigmentation or of lightening, which is higher in Asian skin and with recent tanning1,2
Little or no downtime for toning passes, so treatment fits around workDoes not treat redness, broken capillaries, laxity or active acne
Fractional pico improved atrophic acne scars as much as fractional CO2 in a split-face trial, with less pigmentation afterwards7Several sessions add to the total cost, which is quoted after consultation

For how pico laser compares with Q-switched and yellow laser, see our guide to pico laser vs Q-switched vs yellow laser.

How much does pico laser cost in Singapore?

Pico laser at The Skin Longevity Clinic is quoted only after a consultation with Dr Rachel Ho. The quotation follows the diagnosis. It states the pigment being treated, the treatment mode (spot treatment, low-fluence toning or fractional), the area, the number of sessions and the review plan.

Cost depends on the pigment type, its depth, the area treated and the number of sessions needed. A low-fluence toning pass and a spot or fractional treatment are different treatments. Our pico laser price guide explains each factor and the questions to ask before committing to a package.

Who may not be suitable for pico laser?

Treatment is postponed where the skin is sunburnt, recently tanned, actively inflamed or infected, or where a peel or other aggressive procedure has been performed in the preceding weeks, as skin in any of those states absorbs energy unpredictably and pigments in response to it. Unstable melasma, a history of keloid or abnormal scarring, photosensitising medication and an inability to maintain sun protection all call for caution, as each raises the probability that a treatment session leaves more pigment than it removes. Pregnancy is discussed before any elective procedure.

Pico laser vs Q-switched laser in Singapore: picosecond versus nanosecond pulse duration, photoacoustic versus photothermal effect, heat spread and typical uses compared
Pico laser vs Q-switched laser: pulse duration, effect on pigment, heat spread and typical uses.

Pico laser versus other treatments

Q-switched laser. Nanosecond pulses make this platform effective and lower-cost for many pigment problems. It produces slightly more discomfort and, in the Asian split-face trial, lower six-month improvement rates3. It is available at this clinic as the Q-switched neodymium YAG 1064 nm laser.

Yellow laser (577 to 595 nm). This wavelength targets haemoglobin as well as melanin, so it is used for redness and for melasma with a vascular component. It is not a tattoo or sun-spot laser.

Fractional CO2 laser. Ablative resurfacing remains the stronger option for deeper acne scars. It carries more downtime and, in Asian skin, a higher rate of post-inflammatory hyperpigmentation than fractional pico7. See the fractional CO2 laser page.

Topical therapy and peels. These remain first-line for melasma and post-inflammatory hyperpigmentation, and form the maintenance layer after any laser5. Without that layer, pigment cleared by laser returns as the underlying triggers persist.

Related guides cover post inflammatory hyperpigmentation, sunscreen for melasma, RF microneedling for melasma and RF microneedling vs pico laser for acne scars.

Frequently asked questions

Is pico laser actually effective?

For discrete pigment and tattoos the evidence is strong, with clearance rates of 68 to 93 per cent reported for sun spots4 and more than 70 per cent clearance in 69 to 100 per cent of tattoos8. For melasma and uneven tone the effect is real but partial, and maintenance is required5.

How much does a pico laser session cost?

Pico laser is quoted after a consultation. The quotation depends on the diagnosis, the treatment mode, the area treated and the number of sessions. See the price guide.

What are the disadvantages of pico laser?

The disadvantages are temporary darkening and crusting of treated spots, a small risk of post-inflammatory hyperpigmentation or of lightening in Asian skin, the need for repeated sessions for melasma and scars, and cost. Pico laser also does not treat redness, laxity or active acne.

Why is my pigmentation darker after pico laser?

Treated spots darken and crust for about a week as fragmented pigment is pushed to the surface, then lift. Darkening that persists beyond three to four weeks is usually post-inflammatory hyperpigmentation from heat or sun exposure, or melasma that was mistaken for sun spots and stimulated by the laser. Both are more common in Asian skin and are the reason settings are kept conservative. See why pigmentation returns or darkens after laser.

How long do pico laser results last?

Cleared sun spots and tattoos do not return, although new sun spots form with continued ultraviolet exposure. Melasma and post-inflammatory hyperpigmentation can recur where the triggers persist. Scar improvement is long-lasting because the change is structural, resting on newly formed collagen rather than on pigment removal7.

Is pico laser safe for Asian skin?

Pico laser is appropriate for Asian skin where settings are conservative and the diagnosis is correct. In a meta-analysis of Asian patients, 85 per cent achieved good or excellent clearance2.

Can pico laser remove melasma permanently?

Permanent removal is not achievable, as melasma is a chronic and relapsing condition. Low-fluence 1064 nm pico laser reduces severity5, and maintenance with sun protection and topical therapy holds it under control.

Is pico laser effective for acne scars?

Fractional pico laser matched fractional CO2 laser for atrophic scars in a randomised split-face trial, with less post-inflammatory hyperpigmentation7. Deep or tethered scars need combination treatment, as fractional energy alone does not release the fibrous bands that hold a tethered scar down.

Does pico laser remove pigmentation in one session?

A small number of superficial sun spots may clear in a single session. Most concerns require a series, as each pass fragments only part of the pigment present and the remainder is cleared over the weeks that follow.

Is pico laser painful?

Most patients describe a snapping or prickling sensation, and numbing cream is available for spot and fractional treatment. In the Asian split-face trial, picosecond laser was rated less uncomfortable than Q-switched3.

What should I avoid after pico laser?

Sun exposure, heat, saunas, exfoliants, retinoids and acids should be avoided for the period advised, and crusts should be left to separate on their own. Gentle skincare and broad-spectrum sunscreen are used throughout, as aftercare has a major influence on whether cleared pigment stays cleared.

Dr Rachel Ho’s approach to pico laser

Pigmentation is usually the visible expression of an underlying process, namely inflammation, light sensitivity, barrier weakness, acne, hormonal influence or accumulated sun exposure. Treatment at The Skin Longevity Clinic is directed at clearer and more stable skin rather than at a stronger laser setting, as pigment cleared without addressing its cause returns within months. The plan may combine medical skincare, pigment stabilisation, barrier repair, sun protection, pico laser, other lasers or peels, in the order the diagnosis calls for. Dr Rachel Ho’s experience, commitment to patient safety and professional profile sets her apart from aesthetic doctors and clinics in Singapore. Dr Rachel Ho has also shared her scientific review of pico lasers and her experience with this technology in Pico Laser Review: Benefits, Risks and What the Evidence Shows.

Dr Rachel Ho from The Skin Longevity Clinic's review on Pico laser treatments in Singapore
Glossary of terms used in pico laser reviews

Selected References

  1. Wu DC, Goldman MP, Wat H, Chan HHL. A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations. Lasers in Surgery and Medicine. 2021;53:9 to 49. https://pubmed.ncbi.nlm.nih.gov/32282094/.

  2. Dong W, Wang N, Yuan X, et al. Treatment of pigmentary disorders using picosecond laser in Asian patients: a meta-analysis and systematic review. Dermatologic Therapy. 2021;34:e14709. https://pubmed.ncbi.nlm.nih.gov/33368885/.

  3. Ungaksornpairote C, Manuskiatti W, Junsuwan N, et al. A Prospective, Split-Face, Randomized Study Comparing Picosecond to Q-Switched Nd:YAG Laser for Treatment of Epidermal and Dermal Pigmented Lesions in Asians. Dermatologic Surgery. 2020;46:1671 to 1675. https://pubmed.ncbi.nlm.nih.gov/32604235/.

  4. Mardani G, Nasiri MJ, Namazi N, et al. Treatment of Solar Lentigines: A Systematic Review of Clinical Trials. Journal of Cosmetic Dermatology. 2025;24:e70133. https://pubmed.ncbi.nlm.nih.gov/40145274/.

  5. Feng J, Shen S, Song X, et al. Efficacy and safety of picosecond laser for the treatment of melasma: a systematic review and meta-analysis. Lasers in Medical Science. 2023;38:84. https://pubmed.ncbi.nlm.nih.gov/36897459/.

  6. Li F, Wang Y, Shen Z. Efficacy of Q-switched and picosecond lasers for acquired bilateral nevus of Ota-like macules: a systematic review and exploratory dose-response meta-analysis. Lasers in Medical Science. 2026;41:180. https://pubmed.ncbi.nlm.nih.gov/42560400/.

  7. Sirithanabadeekul P, Tantrapornpong P, Rattakul B, et al. Comparison of Fractional Picosecond 1064-nm Laser and Fractional Carbon Dioxide Laser for Treating Atrophic Acne Scars: A Randomized Split-Face Trial. Dermatologic Surgery. 2021;47:e58 to e65. https://pubmed.ncbi.nlm.nih.gov/32910030/.

  8. Reiter O, Atzmony L, Akerman L, et al. Picosecond lasers for tattoo removal: a systematic review. Lasers in Medical Science. 2016;31:1397 to 1405. https://pubmed.ncbi.nlm.nih.gov/27311768/.

  9. Gurnani P, Williams N, Al-Hetheli G, et al. Comparing the efficacy and safety of laser treatments in tattoo removal: a systematic review. Journal of the American Academy of Dermatology. 2022;87:103 to 109. https://pubmed.ncbi.nlm.nih.gov/32763326/.

  10. Negishi K, et al. Prospective study of removing solar lentigines in Asians using a novel dual-wavelength and dual-pulse width picosecond laser. Lasers Surg Med. 2018;50(8):851–858. doi:10.1002/lsm.22820.
  11. Vachiramon V, et al. Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians. Lasers Med Sci. 2018;33(9):1941–1947. doi:10.1007/s10103-018-2560-3.
  12. Feng J, et al. Comparison of Picosecond and Nanosecond Nd:YAG 1064-nm Lasers in the Treatment of Melasma: A Split-Face Randomized Clinical Trial. Plast Reconstr Surg. 2023;151(4):772–777. doi:10.1097/PRS.0000000000009994.
  13. Wong THS, et al. Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota-like Macules. JAMA Dermatol. 2018;154(10):1226–1228. doi:10.1001/jamadermatol.2018.2671.