Evidence consistently supports combination therapy tailored to scar type, symptoms, and site.
1) First-line clinic-based treatments
Intralesional corticosteroid injections
- Helps flatten and soften keloids and reduce itch/pain
- Often performed as a series (not a one-off)
Silicone gel/silicone sheeting
- Helps with hydration of the scar surface and symptom control
- Commonly used alongside procedures, including after surgery
2) For thicker or more resistant keloids
Steroid + 5-Fluorouracil (5-FU) injections
- Increasingly used when steroids alone are inadequate
- Systematic reviews support effectiveness, with combination approaches commonly used in practice
Laser-assisted scar treatment
- Often used as an adjunct to improve colour and texture and enhance medication penetration
3) Surgery (for selected keloids)
Excision alone has a high recurrence risk, which is why modern practice typically pairs surgery with adjuvant strategies (e.g., injections, silicone, and in selected cases, radiotherapy).